Fig. 6.

Treatment with EKODE exaggerates AOM/DSS-induced colon tumorigenesis in mice. A, Scheme of animal experiment (dose of EKODE = 1 mg/kg/day). B, Quantification of colon tumor in mice (n = 8–9 mice per group). C, H&E histology and IHC staining of PCNA and β-catenin in colon (n = 8–9 mice per group, scale bars: 50 μm). D, Gene expression of Mcp-1, Il-6, Ifn-γ, Pcna, Myc, Jun, Ccnd-1 and Vegf in colon (n = 8–9 mice per group). The results are expressed as means ± SEM. The statistical significance of two groups was determined using Student's t-test or Wilcoxon-Mann-Whitney test.