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. 2021 Jan 27;42:101880. doi: 10.1016/j.redox.2021.101880

Fig. 7.

Fig. 7

EKODE induces inflammation in human colon cancer HCT-116 cells and mouse macrophage RAW 264.7 cells. The cells were treated with 300 nM EKODE or vehicle (DMSO). A, EKODE increased gene expression of pro-inflammatory cytokines in HCT-116 cells after 24-h treatment (n = 5 per group). B, EKODE enhanced IκBα degradation in HCT-116 cells (n = 3 per group). C, EKODE increased nuclear translocation of p65 in HCT-116 cells (n = 3 per group). D, EKODE increased gene expression of pro-inflammatory cytokines in RAW 264.7 cells after 24-h treatment (n = 5 per group). B, EKODE enhanced IκBα degradation in RAW 264.7 cells (n = 3 per group). C, EKODE increased nuclear translocation of p65 in RAW 264.7 cells (n = 3 per group). The results are mean ± SEM. The statistical significance of two groups was determined using Student's t-test or Wilcoxon-Mann-Whitney test. The cell culture experiments were performed with at least 3 independent repeats.