Table 2.

Urinary levels of oxidatively generated damage (8-oxodG, 8-oxoGua, 8-oxoGuo) in healthy subjects and patients with various diseases. As the precise sources of 8-oxodG, and 8-oxoGua (which could be from DNA-, or RNA-related sources, or both) in urine have yet to be defined, we have broadly labelled their origin as ‘DNA’. 8-oxoGuo is from RNA-related source(s). UPLC = ultra performance liquid chromatography.

	Healthy controls	Patients	Methods	Ref.
‘DNA’ oxidation	3.68 (n = 61)	4.58 (n = 57; unipolar and bipolar disorders)	LC-MS/MS	[308]
8-oxodG (ng/mg creatinine)
	2.53 (n = 70)	3.46 (n = 148; bipolar I disorder)	UPLC-MS/MS	[309]
	3.90 (n = 128)	4.35 (n = 87; COPD); 14.6 (n = 100; patients with mechanical ventilation)	LC-MS/MS	[241]
	4.13 (n = 16)	5.23 (n = 46; renal disease)	LC-MS/MS	[310]
	2.80 (n = 73)	4.71 (n = 60; breast cancer)	UPLC-MS/MS	[311]
	-a	5.41 (n = 12; colorectal cancer)	UPLC-MS/MS	[312]
	–	6.76 (n = 508; cardiovascular disease)	UPLC-MS/MS	[313]
	–	4.62 (n = 2721; type 2 diabetes)	UPLC-MS/MS	[314]
	–	5.27 (n = 609; type 2 diabetes)	UPLC-MS/MS	[109]
	2.03 (n = 60)	–	UPLC-MS/MS	[315]
	7.83 (n = 132)	–	LC-MS/MS	[316]
8-oxoGua (ng/mg creatinine)	13.6 (n = 128)	14.7 (n = 87; COPD); 40.2 (n = 100; patients with mechanical ventilation)	LC-MS/MS	[241]
	36.3 (n = 132)	–	LC-MS/MS	[316]
RNA oxidation
8-oxoGuo (ng/mg creatinine)	3.60 (n = 70)	5.44 (n = 148; bipolar I disorder)	UPLC-MS/MS	[309]
	4.90 (n = 128)	8.0 (n = 87; COPD); 27.6 (n = 100; patients with mechanical ventilation)	LC-MS/MS	[241]
	6.80 (n = 16)	15.2 (n = 46; renal disease)	LC-MS/MS	[310]
	–	9.87 (n = 508; cardiovascular disease)	UPLC-MS/MS	[313]
	–	7.82 (n = 2721; type 2 diabetes)	UPLC-MS/MS	[314]
	–	9.58 (n = 608; type 2 diabetes)	UPLC-MS/MS	[109]
	5.89 (n = 60)	–	UPLC-MS/MS	[315]
	12.2 (n = 132)	–	LC-MS/MS	[316]

^aNot available.