Skip to main content
. Author manuscript; available in PMC: 2021 May 12.
Published in final edited form as: J Inherit Metab Dis. 2021 Jan 9;44(3):728–739. doi: 10.1002/jimd.12356

FIGURE 1.

FIGURE 1

Early and late-stage demyelinating lesions in childhood cerebral adrenoleukodystrophy. (a) Very early CCALD lesion in the splenium of the corpus callosum, T2-MRI. (b) Corresponding post-contrast T1-MRI. (c) More prominent early lesion with (d) clear lesional contrast-enhancement. The goal of surveillance is to identify and treat patients at this stage of disease. (e) Advanced parieto-occipital lesion crossing the splenium of the corpus callosum, T2-FLAIR, with (f) a garland of “leading edge” contrast enhancement on T1-post contrast MRI. Patients are often symptomatic at this stage