Table 4.
Global differences in average olfactory measures and CRS-specific measures across the 10 Clusters
| Cluster | Test statistic | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Olfactory measures: | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
| Total TDI score | 26.08 (10.43) | 18.17 (10.03) | 28.57 (6.67) | 30.78 (5.45) | 20.48 (9.11) | 21.53 (10.25) | 25.03 (8.22) | 26.14 (9.04) | 18.90 (9.63) | 17.13 (7.64) | F=7.12** |
| Threshold (T) score | 5.67 (3.27) | 2.77 (2.77) | 6.11 (2.87) | 6.59 (2.80) | 3.13 (2.82) | 3.94 (3.12) | 4.66 (2.39) | 4.41 (2.97) | 2.70 (2.41) | 2.53 (2.11) | F=6.05** |
| Discrimination (D) score | 10.50 (4.06) | 7.60 (3.92) | 11.00 (2.56) | 11.51 (2.18) | 8.80 (3.76) | 9.41 (3.65) | 9.88 (2.75) | 10.56 (3.41) | 7.60 (2.79) | 7.27 (2.40) | F=4.63** |
| Identification (I) score | 9.92 (3.94) | 7.80 (4.40) | 11.45 (2.88) | 12.68 (1.96) | 8.55 (3.93) | 8.19 (4.60) | 10.50 (4.24) | 11.19 (3.94) | 8.60 (4.83) | 7.33 (4.17) | F=5.88** |
| QOD-NS | 7.75 (6.65) | 15.40 (13.42) | 6.50 (7.49) | 5.38 (8.02) | 14.85 (13.37) | 8.56 (8.49) | 9.00 (9.49) | 10.88 (11.66) | 21.80 (14.94) | 17.33 (8.67) | F=4.57** |
| OCES Total | 2.00 (1.73) | 5.67 (3.92) | 1.60 (2.86) | 0.45 (0.83) | 4.22 (3.93) | 3.62 (3.99) | 4.00 (2.00) | 6.50 (5.00) | 4.00 (5.29) | 6.20 (2.78) | F=7.07** |
| CRS-specific measures: | |||||||||||
| LM-CT total score | 14.13 (5.59) | 14.85 (4.39) | 10.07 (6.08) | 10.00 (3.47) | 14.47 (5.79) | 12.04 (5.85) | 13.71 (3.82) | 15.45 (5.72) | 14.00 (7.65) | 17.00 (3.98) | F=2.02* |
| OC Anterior (%) | 38.67 (29.74) | 62.69 (31.14) | 47.43 (32.20) | 38.00 (16.52) | 61.55 (30.38) | 54.13 (34.44) | 46.14 (26.28) | 51.36 (35.55) | 58.33 (34.02) | 78.71 (27.69) | F=1.33 |
| OC Middle (%) | 47.33 (31.53) | 63.77 (29.86) | 48.43 (32.68) | 85.67 (5.51) | 65.00 (31.67) | 62.96 (26.99) | 55.57 (23.05) | 53.00 (32.59) | 72.00 (23.43) | 85.64 (20.80) | F=1.98* |
| OC Posterior (%) | 56.00 (32.74) | 74.85 (22.90) | 52.71 (30.90) | 89.67 (9.07) | 68.00 (30.04) | 67.71 (29.33) | 54.43 (24.54) | 61.27 (33.86) | 77.33 (34.96) | 85.93 (22.13) | F=1.72 |
| LK Endoscopy total score | 5.63 (3.34) | 8.00 (2.48) | 5.93 (4.01) | 2.67 (1.16) | 7.76 (3.75) | 7.07 (3.36) | 6.25 (2.92) | 7.94 (4.37) | 7.33 (3.06) | 8.13 (2.92) | F=1.38 |
| SNOT-22 total score | 43.00 (20.71) | 54.79 (25.16) | 45.00 (19.05) | 59.67 (26.65) | 54.35 (28.34) | 44.84 (22.21) | 44.85 (43.50) | 47.88 (17.96) | 63.80 (13.33) | 55.60 (18.20) | F=0.95 |
| CRS subtypes: | |||||||||||
| No AERD (N = 109; 85.2%) | 8 (100%) | 13 (92.9%) | 13 (86.7%) | 3 (100%) | 15 (88.2%) | 23 (85.2%) | 8 (100%) | 14 (87.5%) | 2 (40.0%) | 10 (66.7%) | ꭕ2=15.68 |
| AERD (N = 19; 14.8%) | 0 (0.0%) | 1 (7.1%) | 2 (13.3%) | 0 (0.0%) | 2 (11.8%) | 4 (14.8%) | 0 (0.0%) | 2 (12.5%) | 3 (60.0%) | 5 (33.3%) | |
| No AFRS (N = 121; 94.5%) | 7 (87.5%) | 12 (85.7%) | 15 (100%) | 3 (100%) | 17 (100%) | 27 (100%) | 7 (87.5%) | 15 (93.8%) | 4 (80.0%) | 14 (93.3%) | ꭕ2=10.92 |
| AFRS (N = 7; 5.5%) | 1 (12.5%) | 2 (14.3%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 1 (12.5%) | 1 (6.3%) | 1 (20.0%) | 1 (6.7%) | |
| CRS Patients (N = 128) | N=8 | N=14 | N=15 | N=3 | N=17 | N=27 | N=8 | N=16 | N=5 | N=15 | |
N=198. SD, standard deviation; T, Sniffin’ Sticks threshold score; D, Sniffin’ Sticks discrimination score; I, Sniffin’ Sticks identification score; QOD-NS, Questionnaire of Olfactory Dysfunction-Negative Statements; OCES, olfactory cleft endoscopy score; OCES total scores were only available for N=159 patients; OCES total scores were available for N=159 patients. CRS, chronic rhinosinusitis; LM-CT, Lund-Mackay computed tomography; OC, olfactory cleft; LK, Lund-Kennedy; SNOT-22, 22-item SinoNasal Outcome Test; AERD, aspirin exacerbated respiratory disease; AFRS, allergic fungal rhinosinusitis; Analyses based on the subset of patients with CRS with sample sizes in each cluster in the last row.
indicates significant differences (p≤0.001) between any two cluster groups using F-test or chi-square (ꭕ2) statistics.