. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Chem Biol Drug Des. 2021 Mar 16;97(6):1137–1150. doi: 10.1111/cbdd.13836

Table 2.

Cytotoxicity [IC₅₀ (μg/mL)] against Vero cells of 21a and CPF (positive control) and their activity [MIC (μg/mL)] on selected clinical isolates of M. tb and two NTM strains.

	IC₅₀		M. tb					M. abs	M. avium
	Vero cells	SI^a	V4207/DS	V2475/MDR^b	KZN494/MDR^b	R506/XDR^c	TF274/XDR^c
21a	≥ 64	≥ 32	4	> 32	> 32	> 32	> 32	> 64	> 64
CPF	≥ 64	≥ 256	0.25	0.25	0.25	2	2	8	0.25

Selectivity index (SI) = IC₅₀(Vero)/MIC(H37Rv)

Resistant to INH and rifampin (RIF)

Resistant to INH, RIF, levofloxacin, ofloxacin, and kanamycin