Table 3.
Technique | Cut-point | Sensitivity (95% CI) | Specificity (95% CI) | Positive predictive value (95% CI) | Negative predictive value (95% CI) | Overall accuracy (95% CI) |
---|---|---|---|---|---|---|
Pre-specified | ||||||
PET grade | ≥ Grade 3 |
162/209–77.5% (71.2 to 83.0%) |
122/146–83.6% (76.5 to 89.2%) |
162/186–87.1% (81.4 to 91.6%) |
122/169–72.2% (64.8 to 78.8%) |
284/355–80.0% (75.4 to 84.0%) |
SUVmax | 2.5 |
158/209–75.6% (69.2 to 81.3%) |
123/146–84.2% (77.3 to 89.7%) |
158/181–87.3% (81.5 to 91.8%) |
123/174–70.7% (63.3 to 77.3%) |
281/355–79.2% (74.6 to 83.3%) |
SURBLOOD | 1.56 |
151/208–72.6% (66.0 to 78.5%) |
124/146–84.9% (78.1 to 90.3%) |
151/173–87.3% (81.4 to 91.9%) |
124/181–68.5% (61.2 to 75.2%) |
275/354–77.7% (73.0 to 81.9%) |
SURLIVER | 1.12 |
151/208–72.6% (66.0 to 78.5%) |
125/146–85.6% (78.9 to 90.9%) |
151/172–87.8% (81.9 to 92.3%) |
125/182–68.7% (61.4 to 75.3%) |
276/354–78.0% (73.3 to 82.2%) |
PET/CT grade | * |
175/207–84.5% (78.9 to 89.2%) |
113/145–77.9% (70.3 to 84.4%) |
175/207–84.5% (78.9 to 89.2%) |
113/145–77.9% (70.3 to 84.4%) |
288/352–81.8% (77.4 to 85.7%) |
Exploratory | ||||||
PET grade | ≥ Grade 2 |
182/209–87.0% (81.8 to 91.3%) |
104/146–71.2% (63.2 to 78.4%) |
182/224–81.3% (75.5 to 86.1%) |
104/131–79.4% (71.4 to 86.0%) |
286/355–80.6% (76.1 to 84.6%) |
SUVmax | 2.05 |
176/209–84.2% (78.5 to 88.9%) |
113/146–77.4% (69.7 to 83.9%) |
176/209–84.2% (78.5 to 88.9%) |
113/146–77.4% (69.7 to 83.9%) |
290/355–81.4% (77.0 to 85.3%) |
SURBLOOD | 1.26 |
170/208–81.7% (75.8 to 86.7%) |
116/146–79.5% (72.0 to 85.7%) |
170/200–85.0% (79.3 to 89.6%) |
116/154–75.3% (67.7 to 81.9%) |
286/354–80.8% (76.3 to 84.8%) |
SURLIVER | 0.96 |
165/208–79.3% (73.2 to 84.6%) |
120/146–82.2% (75.0 to 88.0%) |
165/191–86.4% (80.7 to 90.9%) |
120/163–73.6% (66.2 to 80.2%) |
285/354–80.5% (76.0 to 84.5%) |
CT, computed tomography; PET, positron emission tomography; SURBLOOD, standardised uptake ratio of nodule compared to mediastinal blood pool uptake; SURLIVER, standardised uptake ratio of nodule compared to liver uptake; SUVmax, standardised uptake value
*PET/CT = met one of the following: grade 4 on either PET or CT; Grade 3 on PET and ≥ Grade 2 on CT; ≥ Grade 2 on PET and grade 3 on CT