Skip to main content
. 2020 Nov 1;48(5):1560–1569. doi: 10.1007/s00259-020-05089-y

Table 3.

Comparison of the diagnostic accuracy using pre-specified and optimised diagnostic threshold cut-points

Technique Cut-point Sensitivity (95% CI) Specificity (95% CI) Positive predictive value (95% CI) Negative predictive value (95% CI) Overall accuracy (95% CI)
Pre-specified
 PET grade ≥ Grade 3

162/209–77.5%

(71.2 to 83.0%)

122/146–83.6%

(76.5 to 89.2%)

162/186–87.1%

(81.4 to 91.6%)

122/169–72.2%

(64.8 to 78.8%)

284/355–80.0%

(75.4 to 84.0%)

 SUVmax 2.5

158/209–75.6%

(69.2 to 81.3%)

123/146–84.2%

(77.3 to 89.7%)

158/181–87.3%

(81.5 to 91.8%)

123/174–70.7%

(63.3 to 77.3%)

281/355–79.2%

(74.6 to 83.3%)

 SURBLOOD 1.56

151/208–72.6%

(66.0 to 78.5%)

124/146–84.9%

(78.1 to 90.3%)

151/173–87.3%

(81.4 to 91.9%)

124/181–68.5%

(61.2 to 75.2%)

275/354–77.7%

(73.0 to 81.9%)

 SURLIVER 1.12

151/208–72.6%

(66.0 to 78.5%)

125/146–85.6%

(78.9 to 90.9%)

151/172–87.8%

(81.9 to 92.3%)

125/182–68.7%

(61.4 to 75.3%)

276/354–78.0%

(73.3 to 82.2%)

 PET/CT grade *

175/207–84.5%

(78.9 to 89.2%)

113/145–77.9%

(70.3 to 84.4%)

175/207–84.5%

(78.9 to 89.2%)

113/145–77.9%

(70.3 to 84.4%)

288/352–81.8%

(77.4 to 85.7%)

Exploratory
 PET grade ≥ Grade 2

182/209–87.0%

(81.8 to 91.3%)

104/146–71.2%

(63.2 to 78.4%)

182/224–81.3%

(75.5 to 86.1%)

104/131–79.4%

(71.4 to 86.0%)

286/355–80.6%

(76.1 to 84.6%)

 SUVmax 2.05

176/209–84.2%

(78.5 to 88.9%)

113/146–77.4%

(69.7 to 83.9%)

176/209–84.2%

(78.5 to 88.9%)

113/146–77.4%

(69.7 to 83.9%)

290/355–81.4%

(77.0 to 85.3%)

 SURBLOOD 1.26

170/208–81.7%

(75.8 to 86.7%)

116/146–79.5%

(72.0 to 85.7%)

170/200–85.0%

(79.3 to 89.6%)

116/154–75.3%

(67.7 to 81.9%)

286/354–80.8%

(76.3 to 84.8%)

 SURLIVER 0.96

165/208–79.3%

(73.2 to 84.6%)

120/146–82.2%

(75.0 to 88.0%)

165/191–86.4%

(80.7 to 90.9%)

120/163–73.6%

(66.2 to 80.2%)

285/354–80.5%

(76.0 to 84.5%)

CT, computed tomography; PET, positron emission tomography; SURBLOOD, standardised uptake ratio of nodule compared to mediastinal blood pool uptake; SURLIVER, standardised uptake ratio of nodule compared to liver uptake; SUVmax, standardised uptake value

*PET/CT = met one of the following: grade 4 on either PET or CT; Grade 3 on PET and ≥ Grade 2 on CT; ≥ Grade 2 on PET and grade 3 on CT