. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Bioorg Med Chem Lett. 2021 Mar 9;41:127923. doi: 10.1016/j.bmcl.2021.127923

Table 3.

Activities of compounds 9, 12, 13 and 16 in a βIII-tubulin overexpressing cell line.

Agent	MCF-7 WT EC₅₀ (nM)	MCF-7 TUBB3 βIII-tubuliu EC₅₀ (nM)	Resistance Ratio MCF-7 TUBB3/WT
9	2.0 ± 0.3	3.3 ± 0.4	1.1
12	35.2 ± 4.7	16.8 ±1.5	0.5
13	7.7 ±0.7	9.7 ±1.0	1.3
16	1.7 ±0.2	2.6 ±0.4	1.6
Paclitaxel	194.2	2065.8	10.6