. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Bioorg Med Chem Lett. 2021 Mar 9;41:127923. doi: 10.1016/j.bmcl.2021.127923

Table 4.

Compound activity in a Pgp overexpressing cell line.

Compound No	Compound activity in a Pgp overexpressing cell line^a		Rr

	Parental OVCAR-8 IC₅₀ (nM) ± SD	Pgp overexpressing NCI/ADR-RES IC₅₀ (nM) ± SD
9	9.0 ± 0.7	5.0 ± 0	0.55
10	>5000	>5000	-
11	17 ± 2	8.0 ± 0.7	0.47
12	14 ± 3	11 ± 0.7	0.78
13	2.0 ± 1	4.0 ± 1	2.0
14	49.0 ± 10	44 ± 8.0	0.89
15	31 ± 2	17 ± 3	0.54
16	9.0 ± 1	7.0 ± 3	0.77
17	880 ± 40	730 ±100	0.83
Paclitaxel	5.3 ± 2	800 ± 200	150
CA-4	1.8 ± 0.4	1.8 ± 0.4	1.0