Table 1.
Summary of physiological and physicochemical parameters for the PBK models for DZN and its metabolite DZO in rat and human (Brown et al. 1997; DeJongh et al. 1997; Gearhart et al. 1990)
| Model parameters | Rat | Human | |
|---|---|---|---|
| Physiological parameters | |||
| Body weight (BW; kg) | 0.25 | 70.0 | |
| Percentage of body weight | |||
| Liver | 3.4 | 2.6 | |
| Fat | 7.0 | 21.4 | |
| Rapidly perfused | 4.8 | 5.4 | |
| Slowly perfused | 66.7 | 58.0 | |
| Blood | 7.4 | 7.9 | |
| Flow (l/hr/kg BW0.74) | |||
| Cardiac output | 15.0 | 15.0 | |
| Percentage of cardiac output | |||
| Liver | 25.0 | 22.7 | |
| Fat | 9.0 | 5.2 | |
| Rapidly perfused | 51.6 | 43.0 | |
| Slowly perfused | 14.4 | 29.1 | |
| Tissue: blood partition coefficients for DZN | |||
| Liver | 13.7 | 7.1 | |
| Fat | 211.0 | 137.7 | |
| Rapidly perfused | 13.7 | 7.1 | |
| Slowly perfused | 8.7 | 4.5 | |
| Tissue: blood partition coefficients for DZO | |||
| Liver | 3.9 | 2.6 | |
| Fat | 89.6 | 72.4 | |
| Rapidly perfused | 3.9 | 2.6 | |
| Slowly perfused | 2.4 | 1.9 |