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. 2021 Mar 14;95(5):1573–1593. doi: 10.1007/s00204-021-03015-1

Table 3.

Comparison of predicted BMDL10 values to reported BMDL10 values and to the NOAEL values established by USEPA (2016), EFSA (2006) and JMPR (2016) for DZN

PODs Reported NOAEL from EFSA and JMPR (adult rat) (mg/kg bw) Reported BMDL10 from EPA (adult rat) (mg/kg bw) Reported BMDL10 from EPA (pups) (mg/kg bw Predicted BMDL10 for adult rat (mg/kg bw) Predicted BMDL10 for rat pups (mg/kg bw) Predicted BMDL10 for human (mg/kg bw)
Diazinon 2.5 4.8 3.0 12.6 6.3a 2.1

aValue derived from the BMDL10 for adult rats taking into account the results from an in vivo study (Padilla et al. 2004), showing that pups are expected to be 2-fold more sensitive than adults