Table 3.
Comparison of predicted BMDL10 values to reported BMDL10 values and to the NOAEL values established by USEPA (2016), EFSA (2006) and JMPR (2016) for DZN
| PODs | Reported NOAEL from EFSA and JMPR (adult rat) (mg/kg bw) | Reported BMDL10 from EPA (adult rat) (mg/kg bw) | Reported BMDL10 from EPA (pups) (mg/kg bw | Predicted BMDL10 for adult rat (mg/kg bw) | Predicted BMDL10 for rat pups (mg/kg bw) | Predicted BMDL10 for human (mg/kg bw) |
|---|---|---|---|---|---|---|
| Diazinon | 2.5 | 4.8 | 3.0 | 12.6 | 6.3a | 2.1 |
aValue derived from the BMDL10 for adult rats taking into account the results from an in vivo study (Padilla et al. 2004), showing that pups are expected to be 2-fold more sensitive than adults