Table 1.
Socio-demographic and clinical characteristics and comparisons of the samples.
| AR, n = 32 | HC, n = 27 | Statistics AR vs HC | AR-unwell, n = 15 | AR-well, n = 17 | Statistics AR-unwell vs AR-well vs HC | |
|---|---|---|---|---|---|---|
| Age, mean years (SD) | 33.1 (5.2) | 33.7 (3.9) | p = 0.62 (t = 0.51) | 32.1 (5.2) | 33.9 (5.3) | p = 0.51 (F = 0.68) |
| FSIQ, mean (SD) | 96.6 (14.9) | 105.0 (13.9) | p = 0.03 (t = 2.22) | 92.1* (16.6) | 100.5 (12.3) | p = 0.03 (F = 3.94) |
| Ethnicity (% Caucasian) | 62.5 (20) | 85.2 (23) | p = 0.14 (χ2 = 3.92) | 53.3 (8) | 70.6 (12) | p = 0.13 (χ2 = 7.10) |
| Time between delivery and MRI, mean weeks (SD) | 16.4 (6.1) | 16.0 (4.8) | p = 0.78 (t = −0.29) | 17.1 (7.4) | 15.8 (4.8) | p = 0.77 (F = 0.27) |
| Parity (% primiparity) | 62.5 (20) | 48.1 (13) | p = 0.32 (χ2 = 1.01) | 53.3 (8) | 70.6 (12) | p = 0.34 (χ2 = 2.19) |
| Handedness (% right) | 93.8 (30) | 85.2 (23) | p = 0.19 (χ2 = 3.33) | 93.3 (14) | 94.1 (16) | p = 0.22 (χ2 = 5.74) |
| Age of onset, mean years (SD) | 20.2 (5.5) | N/A | N/A | 20.3 (5.7) | 20.1 (5.6) | p = 0.92 (t = −0.11) |
| Time between illness onset and MRI, mean years (SD) | 13.5 (5.8) | N/A | N/A | 12.1 (5.9) | 14.7 (5.5) | p = 0.22 (t = 1.24) |
| Medications (% yes)a | 62.5 (20) | N/A | N/A | 66.7 (10) | 58.8 (10) | p = 0.65 (χ2 = 0.21) |
| Antipsychotic daily dose, mean CPZ mg equivalents (SD)a | 260.7 (271.9) | N/A | N/A | 287.5 (221.1) | 224.9 (348.1) | p = 0.69 (t = −0.41) |
| PANSS Total score, mean (SD)a | 33.4 (4.4) | 30.7 (1.1) | p = 0.002 (U = 198.5) | 33.9* (5.1) | 33.0 (3.9) | p = 0.005 (K = 10.67) |
| YMRS Total score, mean (SD)a | 0.8 (1.6) | 0.3 (0.7) | p = 0.14 (U = 324.5) | 1.3 (2.2) | 0.4 (0.8) | p = 0.20 (K = 3.23) |
| HDRS Total score, mean (SD)a | 5.7 (5.3) | 2.7 (1.9) | p = 0.01 (U = 245.0) | 6.8* (6.4) | 4.8 (4.5) | p = 0.02 (K = 7.48) |
| GAF Total score, mean (SD)a | 73.6 (12.3) | 90.6 (6.2) | p = 0.00 (U = 53.0) | 65.9* (3.6) | 80.0 (8.9) | p = 0.00 (K = 36.9) |
| CGI Total score, mean (SD)a | 1.9 (1.3) | 1.1 (0.4) | p = 0.00 (U = 227.0) | 2.6* (1.5) | 1.4 (0.8) | p = 0.00 (K = 26.9) |
AR at risk, HC healthy controls, AR-unwell at risk women who developed a postpartum relapse, AR-well at risk who did not develop a postpartum relapse, SD standard deviation, FSIQ full scale intelligence quotient, CPZ chlorpromazine
*Significant post-hoc comparison relative to HC
aAt 8-week assessment
Bold values represent statistically significant values (p < 0.05)