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. 2021 May 11;12:2683. doi: 10.1038/s41467-021-22993-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The genome was divided into consecutive, non-overlapping 4-kb bins, which are stacked according to their genomic position from the top of chromosome 1 to the bottom of chromosome 5. Pericentromeric regions are indicated (peri.1 to peri.5). H2A.W enrichment in the WT (log2 ChIP/H3) is shown as a heat map on the left. Other heat maps show changes in H1 levels (h2a.w-2/WT; log2 ChIP/H3), changes in chromatin accessibility (log2 mutant/WT; ATAC-seq read depth), and changes in CHG and CHH DNA methylation (mutant minus WT) in h2a.w-2 versus WT and in h1 h2a.w versus WT.