Fig. 3. Time course of non-cardiac and cardiac phenotypes associated with wild-type ATTR cardiomyopathy vs. non-amyloid heart failure prior to the diagnosis of heart failure.

The proportion of patients at each time point (years before heart failure diagnosis) with a first diagnosis of an associated feature (phenotype). The cumulative proportion of patients with each particular phenotype is equal to the sum of the proportions from each of the years preceding the heart failure diagnosis. ATTR-CM, amyloidogenic transthyretin cardiomyopathy.