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. 2021 May 11;11:10012. doi: 10.1038/s41598-021-89476-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genomic network analysis showing the central role of genes related with cell cycle pathway. Genes hypermethylated (circled in pink) from different studies were involved into common biological processes suggesting that they work together. PPI analysis pointed to external stimulus, such as DNA damage, UV stress, all-trans-retinoic acid that could activate a cellular signalization to epithelial-mesenchymal transition (EMT), adipogenesis, angiogenesis, immortality, cell growth, cell cycle and proliferation. Image done using the public repository SIGnaling Network Open Resource 2.0 (SIGNOR 2.0).