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. 2021 May 11;11:10012. doi: 10.1038/s41598-021-89476-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Transcription profile reveals CD44 is highly expressed in HPV-HNC. (B) Correlation between gene expression and epigenetic alteration. (C) Validation of the protein expression in an independent cohort of 100 HNC with long-term follow-up. Representative immunohistochemical staining for CD44 in head and neck cancer. The cytoplasmic membrane immunoreactivity for CD44 was clearly identified. Original magnification: 400×. (D) CD44 protein was differentially expressed HPV+ and HPV- HNC patients. Confidence intervals (CI 95%) show relative percentage and IHC intensity value. Y-axis represents numerical values corresponding to the percentage and intensity of expression. (E) Survival curves analysis according to the Kaplan–Meier method showing that patients with positive expression of CD44 had shorter survival rate in comparison with negative immunostaining (log-rank test, P < 0.01).