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. 2021 May 11;11:10012. doi: 10.1038/s41598-021-89476-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Regulatory network of selected hypermethylated genes associated with risk factors in head and neck cancer. Genes regulated by methylation from independent published studies in head and neck cancer (such as GAB1, TGFB, and JAK3) belongs to similar networks known to play a fundamental role in cancer progression. These methylated genes are targeted by the drugs, including TGF-beta receptor type II (Lerdelimumab, Suramin, and Interferon beta), GAB1-RA (Primidone, Flumazenil, Oxazepam, Flurazepam, Methylphenobarbital, Clorazepate, Ganaxolone, Clomethiazole, Zaleplon, Ocinaplon, Methyprylon, Indiplon, Zolpidem, Pentobarbital and Secobarbital), JAK 3 (Tofacitinib). Graphs were extracted from Metacore, Thompson Reuters (https://portal.genego.com).