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. 2020 Oct 23;48(5):1339–1350. doi: 10.1007/s00259-020-05057-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — In vitro uptake determining binding and IC₅₀ values of lutetium-177-labeled PSMA-617, PSMA-I&T, and nanobody JVZ-007. a Uptake (expressed in percentage of the added activity (%AA)) of the different tracers per 100,000 cells in four PSMA-expressing cell lines. b IC₅₀ curves of in vitro displacement assays using DU145-PSMA #15 cells (IC₅₀ curves of the other three cell lines can be found in the supplemental data (Suppl. Fig. 1)) c IC₅₀ values of all in vitro uptake assays, each dot represents a different PSMA-expressing cell line. The error bars represent the standard deviation. Asterisks indicate significance (**P ≤ 0.01, ****P ≤ 0.0001)