Fig. 3.

In vitro autoradiography assays determining the binding of lutetium-177-labeled PSMA-617, PSMA-I&T, and JVZ-007 to human kidney (K), salivary gland (S), and PC295 PDX cryosections. Samples of different patients (indicated with the different numbers) were used. a Representative images of the autoradiography results and corresponding H&E staining. b Autoradiography results quantified on human kidney tissue and c) when normalized for lutetium-177-labeled PSMA-617. d Autoradiography results quantified on human salivary gland tissue (‘b’ on the x-axis indicates separate analysis from the same patient) and e when normalized for lutetium-177-labeled PSMA-617. Asterisks indicate significance (****P ≤ 0.0001). All error bars indicate standard deviation