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. 2020 Oct 23;48(5):1339–1350. doi: 10.1007/s00259-020-05057-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — In vivo biodistribution of [¹⁷⁷Lu]Lu-PSMA-617 and [¹⁷⁷Lu]Lu-PSMA-I&T in mice bearing PC295 PDX. a Representative SPECT/CT images at 4, 8, and 24 h p.i. White arrows indicate the PC295 PDX, green arrows the kidneys, and the yellow asterisks indicate the bladder. b Biodistribution of [¹⁷⁷Lu]Lu-PSMA-617 (expressed in percentage of injected activity per grams of tissue (%IA/g)) and c corresponding tumor-to-kidney ratio (error bars indicate standard deviation). d Biodistribution of [¹⁷⁷Lu]Lu-PSMA-I&T and e corresponding tumor-to-kidney ratio (for a–d: error bars indicate standard deviation). f Absorbed dose per 30 MBq (error bars indicate standard error of the mean). Asterisks indicate significant differences between tracers (****P ≤ 0.0001)