TABLE 1.
Patient Characteristics
| Total Patients (N = 753) |
Patients Without Cardiac Biopsy (n = 649) |
Patients With Cardiac Biopsy (n = 104) |
|||
|---|---|---|---|---|---|
| Total | ATTR-CA* (n = 127) | No Amyloidosis (n = 434) | ATTR-CA (n = 69) | No Amyloidosis (n = 22) | |
| Age, yrs | 76.7 ± 10.9 | 79.4 ± 8.4 | 76.8 ± 11.4 | 72.9 ± 8.5 | 69.9 ± 8.3 |
| Male | 513 (68) | 96 (76) | 264 (61) | 59 (86) | 17 (77) |
| Racial/ethnic background | |||||
| White | 537 (71) | 86 (68) | 321 (74) | 48 (70) | 15 (68) |
| Black | 106 (14) | 22 (17) | 58 (13) | 10 (14) | 5 (23) |
| Hispanic | 49 (7) | 5 (4) | 27 (6) | 5 (7) | 1 (5) |
| Other/unknown | 61 (8) | 15 (12) | 28 (6) | 6 (9) | 1 (5) |
| Echocardiography | |||||
| LV ejection fraction, % (n = 693) | 55 (38–60) | 47 (35–56) | 55 (43–63) | 46 (31–57) | 50 (30–60) |
| IVS, mm (n = 736) | 13 (11–15) | 15 (13–18) | 12 (10–13) | 16 (15–19) | 11 (10–14) |
| LVPWT, mm (n = 735) | 12 (10–14) | 15 (13–16) | 11 (9–12) | 16 (14–18) | 10 (9–13) |
| Left atrial volume index, ml/m2 (n = 556) | 50 (40–63) | 51 (43–62) | 50 (39–65) | 46 (41–52) | 51 (46–78) |
| PYP visual score | |||||
| Grade 0 | 307 (41) | 2* (1) | 278 (64) | 0 (0) | 12 (55) |
| Grade 1 | 177 (24) | 1* (1) | 153 (35) | 4 (6) | 7 (32) |
| Grade 2 | 37 (5) | 5 (3) | 3 (1) | 2 (3) | 3 (14) |
| Grade 3 | 232 (31) | 119 (94) | 0 (0) | 63 (91) | 0 (0) |
| PYP H:CL (n = 751) | |||||
| <1.5 | 502 (67) | 5 (4) | 430 (100) | 3 (4) | 21 (95) |
| ≥1.5 | 249 (33) | 122 (96) | 2 (0) | 66 (96) | 1 (5) |
Values are mean ± SD, n (%), or median (interquartile range). Patient characteristics in the total cohort, patients diagnosed or negative for ATTR-CA by imaging, and patients diagnosed or negative for ATTR-CA by cardiac biopsy are shown.
*
Three patients with grade 0 or 1 scans met criteria for CA on the basis of typical echocardiographic features, Phe64Leu mutation, and extracardiac biopsies showing ATTR.
ATTR-CA = amyloid transthyretin cardiac amyloidosis; CA = cardiac amyloidosis; H:CL = heart to contralateral chest ratio; IVS = interventricular septal thickness on echo; PYP = technetium Tc 99m pyrophosphate; LV = left ventricular; LVPWT = left ventricular posterior wall thickness on echo.