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. 2020 Nov 12;598(7879):144–150. doi: 10.1038/s41586-020-2907-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Panels a–f show data from the same exemplary cell. a, Membrane potential responses to the consecutive step current injections. Hyperpolarizing currents were used to compute the input resistance (274.80 MOhm) and membrane time constant tau (21.95 ms). b, The first five traces showing spikes were used to compute ISI adaptation index (1.26), ISI average adaptation index (1.15), AP amplitude adaptation index (0.91) and AP amplitude average adaptation index (0.99). c, The first AP elicited in this neuron. It was used to compute AP threshold (−40.18 mV), AP amplitude (81.17 mV), AP width (0.80 ms), AHP (−12.60 mV), ADP (0 mV), UDR (1.62) and latency of the first spike (69.28 ms). d, Regression line gives the rheobase estimate (20.44 pA). e, The highest firing trace with 32 APs. This trace was used to estimate the ISI CV (0.27), ISI Fano factor (0.0014 ms), AP CV (0.17) and AP Fano factor (1.32 mV). f, The lowest hyperpolarization trace was used to compute the sag ratio (1.17), sag time (0.26 ms), sag area (31.16 mV⋅ms) and rebound (17.84 mV). g, Eight important electrophysiological features are shown for all cells across all t-types. For t-types with at least three cells, horizontal lines show median values. See Supplementary File 2 for all electrophysiological features.