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. 2021 Apr 30;20:1533033820980115. doi: 10.1177/1533033820980115

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Target relationship between miR-375 and YAP1 and expression of related proteins in the Wnt/β-catenin axis. (A) database (http://starbase.sysu.edu.cn) sought the targeting point of miR-375 and YAP1; (B) targeting relationship between miR-375 and YAP1 was verified by dual-luciferase reporter gene assay, compared with negative control group, ***p < 0.001; (C, D) YAP1 expression in OC tissues, non-cancerous tissues and OC cell lines was detected with RT-qPCR and Western blot analysis, compared with control group, ***p < 0.001; (E) Wnt/β-catenin signaling pathway-related protein after overexpressing miR-375 was measured with Western blot analysis, compared with control group, ***p < 0.001; two-way ANOVA and Tukey’s multiple comparisons test was applied to determine statistical significance, Repetitions = 3. miR: microRNA; YAP1: Yes-associated protein 1; OC: ovarian cancer; RT-qPCR: reverse transcription quantitative polymerase chain reaction; ANOVA: analysis of variance.