Table 3.
Multivariable analysis for association between acute kidney injury and overall survival and dialysis free survival.
| Hazard of death | Hazard of death or dialysis | |||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| All patients (n = 2934) | ||||
| Age | 1.04 (1.04, 1.05) | < 0.001 | 1.04 (1.04, 1.05) | < 0.001 |
| Female gender | 0.94 (0.84, 1.06) | 0.339 | 0.94 (0.84, 1.06) | 0.341 |
| Pre-existing health conditionsa | 2.17 (1.84, 2.56) | < 0.001 | 2.20 (1.87, 2.59) | < 0.001 |
| Max AKI level | ||||
| None | 1 | 0.166 | 1 | 0.015 |
| Mild | 0.98 (0.85, 1.13) | 0.99 (0.86, 1.14) | ||
| Moderate—severe | 1.12 (0.97, 1.28) | 1.19 (1.04, 1.36) | ||
All models were additionally adjusted for baseline eGFR which was significant in all models (p < 0.001). eGFR was modelled using second degree fractional polynomials (FP(3,3) provided best fit in all models) to allow for the non-linear relationship with hazard of death. The nature of his relationship is illustrated in Figure S6; hazard of death was highest among patients with low or high eGFR, and lowest among patients with eGFR between 70 and 100.
AKI acute kidney injury ICU, HR hazard ratio, CI confidence interval.
aRecorded according to the APACHE score chronic organ insufficiency.