. 2021 May 11;12:2582. doi: 10.1038/s41467-021-22885-8

Table 1.

Clinical features of the orthotopic, immunocompetent GBM models.

Murine GBM cell line	Recapitulates features of human GBM	Response to αPD1	Mutation status	Reference
005GSC^a	Stem-cell rich, invasive	Non-responder	IDH-wildtype	^73,82,83
CT2A^a	Low mutational load	Non-responder	IDH-wildtype	^27,84
GL261-MGH^a	Highly vascularized, necrotic, invasive	Non-responder	IDH-wildtype	^{26,27,63,64,84}

^aOrthotopic intracranial implantation through cranial window/pocket using stereotactic devise (10, 5, and 7.5 × 104 cells for GL261-MGH, CT2A, and G005 tumors, respectively). Tumor growth is monitored by ultrasound imaging or blood Gluc assay⁶³.