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. 2021 May 11;12:2622. doi: 10.1038/s41467-021-22925-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a, b Body weight curve and body weight change of UCP1^−/− mice on a high-fat diet administered daily with either a jelly containing vehicle (control) or BIBO3304 for 8 weeks. Data are mean ± s.e.m, n = 6 per group (control: open circle; BIBO3304: filled circle). p values by two-way repeated measures ANOVA. c Whole-body fat mass of vehicle- and BIBO3304-treated UCP1^−/− mice on a HFD determined by DEXA at baseline and after 2 weeks of treatment. d Dissected weights of individual WAT from inguinal (WATi), epididymal (WATe), mesenteric (WATm), retroperitoneal (WATr) and total weights of these 4 depots (WATsum) at cull. e Whole-body lean mass of vehicle- and BIBO3304-treated UCP1^−/− mice on a HFD determined by DEXA at baseline and after 2 weeks of treatment. Data are mean ± s.e.m, n = 6 per group (control: open red; BIBO3304: red). p values by two-sided t test (c, d, e). f, g Energy expenditure, h, i RER of vehicle- and BIBO3304-treated UCP1^−/− mice on a HFD over a 24 h course during an indirect calorimetry study at 13 weeks of age. Data are mean ± s.e.m, control n = 6 (open circle), BIBO3304 n = 5 (filled circle). p values by two-way repeated measures ANOVA. j Temperature measured by infra-red camera of BAT and lumbar back regions of HFD-fed UCP1^−/− mice given vehicle or BIBO3304 jelly at 11 weeks of age. Data are mean ± s.e.m, control n = 6 (open red), BIBO3304 n = 5 (red). p values by two-sided t test within the same region. k Glucose levels in an intraperitoneal glucose tolerance test (GTT) in vehicle- and BIBO3304-treated UCP1^−/− mice on a HFD at 13 weeks of age. Data are mean ± s.e.m. n = 6 per group (control: open circle; BIBO3304: filled circle). p values by two-way repeated measures ANOVA. ns non-significance. Source data are provided as a Source Data file.