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. 2021 May 11;12:2622. doi: 10.1038/s41467-021-22925-3

Fig. 9. Peripheral Y1R antagonism activates thermogenesis in human adipocytes.

Fig. 9

a mRNA levels of thermogenic and lipogenic markers in subcutaneous white adipose tissue (SAT) of lean and obese subjects. Data are mean ± s.e.m, lean n = 9 (white bar), obese n = 18 (cyan bar), #p < 0.05, ##p < 0.01, ###p < 0.001 by two-tailed t test. b, mRNA levels of thermogenic and lipogenic markers in visceral adipose tissue (VAT) of lean and obese subjects. Data are mean ± s.e.m, lean n = 10 (white bar), obese n = 19 (cyan bar). #p < 0.05, ##p < 0.01, ###p < 0.001 by two-tailed t test. c mRNA levels of thermogenic and lipogenic markers in stromal vascular fraction (SVF) isolated from obese subjects cultured and differentiated ex vivo and treated with Y1R-specific agonist [Leu31,Pro34]NPY and/or antagonist BIBO3304 for 48 h. Data are mean ± s.e.m, n = 5–8 per group (control: black; BIBO3304: blue; [Leu31,Pro34]NPY: green; BIBO3304 + [Leu31,Pro34]NPY: mustard). *p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA with Tukey’s multiple comparisons test. Source data are provided as a Source Data file.