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. 2021 May 11;12:2648. doi: 10.1038/s41467-021-22914-6

Fig. 1. Innate fear odor 2MT induces hypothermia and tail temperature increase via Trpa1.

Fig. 1

a Schematic of 2MT-induced hypothermia assay in mice. b Time-lapsed thermal images showing tail and skin temperature changes in wild-type (upper) and Trpa1−/− (bottom) mice during 2MT treatment. Skin (c), core (e) and tail (g) temperature curves of wild-type and Trpa1−/− mice (n = 5 or 6) before and during 2MT treatment. Average skin (d), core (f) and tail (h) temperature changes of wild-type and Trpa1−/− mice (n = 5 or 6) during 2MT treatment. i Representative images showing 2MT-induced c-Fos expression in PBel, PSTh, and NTS of wild-type and Trpa1−/− mice. j Quantitative analysis of 2MT-evoked c-Fos expression in PBel, PSTh, and NTS in wild-type and Trpa1−/− mice (n = 5). c–h, j Data are mean ± SEM; two-side Student’s t test. Scale bars, 100 µm.