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. 2021 May 11;12:2648. doi: 10.1038/s41467-021-22914-6

Fig. 4. Activation of NTS-projecting PSTh neurons evokes hypothermia and tail temperature increase.

Fig. 4

a Schematic of optogenetic activation of the PSTh-NTS pathway in wild-type mice. b Representative image showing c-fos expression in ChR2-labeled PSTh neurons after photoactivation (n = 6). c Time-lapsed thermal images of ChR2-expressing mice during photoactivation of the NTS-projecting PSTh neurons. Tail (d), skin (f), and core (h) temperature curves of EGFP-expressing (n = 6) and ChR2-expressing mice (n = 6) before and during photoactivation of the NTS-projecting PSTh neurons. Average tail (e), skin (g), and core (i) temperature changes of EGFP-expressing (n = 6) and ChR2-expressing mice (n = 6) during photoactivation of NTS-projecting PSTh neurons. d–i Data are mean ± SEM; two-side Student’s t test. Scale bar, 100 µm.