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. 2021 May 11;12:2648. doi: 10.1038/s41467-021-22914-6

Fig. 7. Inhibition of PSTh-projecting PBel neurons diminishes 2MT-evoked hypothermia and tail temperature increase.

Fig. 7

a Schematic of chemogenetic inhibition PSTh-projecting PBel neurons. b Representative image of hMD4i-labeled PSTh-projecting PBel neurons (n = 2). c Time-lapsed thermal images of mCherry-expressing mice and hM4Di-expressing mice during 2MT treatment following administration of C21. Tail (d), skin (f), and core (h) temperature curves of mice with (hM4Di, n = 8 or 9) or without (mCherry, n = 6) inactivation of PSTh-projecting PBel neurons before and during 2MT treatment. Average tail (e), skin (g), and core (i) temperature changes of mice with (hM4Di, n = 8 or 9) or without (mCherry, n = 6) inactivation of PSTh-projecting PBel neurons during 2MT treatment. di Data are mean ± SEM; two-side Student’s t test. Scale bar, 100 µm.