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. 2021 May 11;12:2674. doi: 10.1038/s41467-021-22987-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a ELISA of IL-1β, IL-18, and TNF-α in supernatants from mouse peritoneal macrophages silenced of β-TrCP1, treated with indicated stimuli (mean ± SD, two-way ANOVA with Bonferroni test, β-TrCP1 siRNA vs. Ctrl siRNA, left panel: **P = 0.0024, ***P = 0.0006, ***P = 0.0006 in sequence; middle panel: *P = 0.0169, **P = 0.0011, **P = 0.0081 in sequence; n = 3 independent experiments). b Immunoblot analysis of extracts from mouse peritoneal macrophages silenced of β-TrCP1, then stimulated for indicated times with LPS. c ELISA of IL-1β, IL-18, and TNF-α in supernatants from Yap^fl/fl lyz2-Cre or Yap^fl/fl peritoneal macrophages silenced of β-TrCP1, treated with indicated stimuli (mean ± SD, two-way ANOVA with Bonferroni test, Yap^fl/fl lyz2-Cre + β-TrCP1 siRNA vs. Yap^fl/fl lyz2-Cre + Ctrl siRNA, left panel: **P = 0.0023, **P = 0.0018, **P = 0.0047 in sequence; middle panel: **P = 0.0084, **P = 0.0066, *P = 0.0498 in sequence; n = 3 independent experiments). d Immunoblot analysis of lysates from Yap^fl/fl lyz2-Cre or Yap^fl/fl mouse peritoneal macrophages silenced of β-TrCP1, treated with indicated stimuli. Similar results were obtained from three independent experiments. Source data are provided as a Source Data file.