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. 2021 May 11;12:2674. doi: 10.1038/s41467-021-22987-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a, b Yap^fl/fl lyz2-Cre or Yap^fl/fl mice were intraperitoneal injected 20 mg/kg LPS for 6 h, ELISA analysis of serum levels of IL-1β and TNF-α (a), H&E staining of lung tissue sections(b) Scale bars, 50 μm (mean ± SEM, two-way ANOVA with Bonferroni test, Yap^fl/fl lyz2-Cre vs. Yap^fl/fl, ***P < 0.0001, n = 10 biologically independent mice). c, d Yap^fl/fl lyz2-Cre or Yap^fl/fl mice were intraperitoneally injected with 1 mg monosodium urate for 6 h, ELISA analysis of IL-1β (c) and quantification of neutrophils (d) in the peritoneal cavity fluid (mean ± SEM, two-way ANOVA with Bonferroni test, Yap^fl/fl lyz2-Cre vs. Yap^fl/fl, ***P < 0.0001 (c), ***P < 0.0001 (d) in sequence, n = 8 biologically independent mice). e The model of YAP in NLRP3 inflammasome activation. YAP maintains the stability of NLRP3 by blocking/masking the interaction between NLRP3 and the E3 ligase β-TrCP1, which promotes the proteasomal degradation of NLRP3 via K27-linked ubiquitination at lys380. Cellular nutrient/density status, activating the Hippo-YAP pathway, impairs NLRP3 inflammasome activation in a YAP-dependent manner. Source data are provided as a Source Data file.