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. 2021 May 11;12:2670. doi: 10.1038/s41467-021-22958-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Indicated is the percent of 150 COVID-19 patients tested at the in-hospital visit, that had IgG, IgM, and IgA to SARS-CoV-2 antigens detected with LIPS, when sampled during the first or second two weeks from symptoms onset. b, c Sera of COVID-19 patients, collected at the indicated timepoints from symptoms onset, were measured by LV-based-neutralization assay and the LIPS indicated in gray labels above each row/column. In (b) are Ig to RBD and in (c) Ig to S1 + S2. Boxes under the diagonal show each correlation plot of the reciprocal of ID50 and arbitrary units after log1p conversion. Dots correspond to individual measurements, the black line represents the regression line and the gray area is 95%CI. Boxes on the diagonal show as histograms the distribution of values in each assay. Boxes above the diagonal show the corresponding Pearson correlation analysis coefficients. Asterisks correspond to the following p values: ***p ≤ 0.001; **p ≤ 0.01; *p ≤ 0.05. d Correlation matrix of the indicated variables in weeks 1–2. For each pair, Pearson’s correlation coefficient is shown as number and on a color scale. Statistically non-significant correlations are crossed. Source data are provided as a Source Data file.