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. 2021 May 11;11:9946. doi: 10.1038/s41598-021-89295-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Proportion of Parasite clearance phenotypes: we had classified four different parasite clearance phenotypes depending on the parasite clearance time. Parasites, those who cleared within 36 h of drug administration were classified as Rapid clearing parasite (RCP) whereas parasites cleared by 48 h of drug exposure were designated as Parasite clearance normal (PCN). In patients, those whose parasites were cleared by > 48 h to ≥ 72, were designated as Delayed clearing parasite (DCP). Parasites were not cleared after 72 h of drug exposure were designated as Very slow clearing parasite (VSCP). (B) Frequency of different Parasite clearance phenotypes in relation to PC_1/2: Parasite clearance normal (PCN) phenotype (40%), was most prevalent followed by delayed clearing parasite (DCP; 28.88%) and rapid clearing parasite (RCP; 26.11%). Interestingly, 5% of isolates represented VSCP phenotypes. We found low median PC_1/2 in RCP (2.6 h) and PCN phenotype (2.8 h). Higher PC_1/2 was observed in DCP phenotype (4.2 h) while very high median PC_1/2 was recorded in VSCP phenotype (5.6 h) which proved these phenotypes perhaps less sensitive to ASSP therapy.