Table 3.
PCR | Drug | Study population (n) | Day-3 positive parasite | ETF (n) | LTF (n) | ACPR (n) | Recrudescence (n) | Re-infection (n) |
---|---|---|---|---|---|---|---|---|
PCR uncorrected | ASSP | 180 | 9 (5%) | 7a (3.9%) | 12 (6.7%) | 159 (88.3%) | – | – |
PCR corrected | ASSP | 180 | 9 (5%) | 7a (3.9%) | 10b (5.6%) | 161 (89.4%) | 10 (5.6%) | 2 (1.1%) |
ACPR, ETF and LTF stand for adequate clinical parasitological response, early treatment failure and late treatment failure, respectively, whereas ASSP stand for artemisinin-sulfadoxine-pyrimethamine.
aOne patient did not attain the adequate plasma DHA concentration and in another patient, we failed to adapt the in vitro culture for RSA assay.
bInitially reappearance of infection was observed in 12 patients (6.7%), but analyses of msp1, msp2, and glurp gene confirmed that among those 12 patients, 10 (5.5%) were true recrudescence (LTF) case.