Table 5.
Distribution of parasite phenotype and genotypes in day-3 positive parasites.
| > 72 h (+) case | Plasma artesunate (nmol/L) | Parasite load on day-0 pd/µL | Parasite load on day-3 pd/µL | Fever on day 0 (°C) | Fever on day 3 (°C) | RSA(0–3 h) (in %) | Treatment response (in h) | Kelch13 genotype | Atpase6 haplotype | Pfmdr1 haplotype | Pfcrt haplotype | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.5 h | 3 h | PCT | PC1/2 | ||||||||||
| Case1 | 4023 | 2361 | 19,368 | 237 | 39.6 | 38.1 | 2.4 | 96 | 6.2 | Wild | LEAAS | YYSND | SVMNTNT |
| Case 2 | 4196 | 2147 | 8432 | 96 | 38.5 | 38 | 3.0 | 102 | 5.6 | Wild | LEAAS | YFSND | CVIETNT |
| Case 3 | 3833 | 2051 | 21,641 | 356 | 38.7 | 38.1 | 2.1 | 108 | 5.6 | Wild | LEAAS | YFSND | SVMNTST |
| Case 4 | 4077 | 1952 | 70,846 | 611 | 38.4 | 37.8 | 2.6 | 108 | 5.8 | Wild | LEAAS | YFSND | SVMNTST |
| Case 5 | 4086 | 2052 | 56,855 | 123 | 38.8 | 37.5 | 1.7 | 96 | 5.3 | Wild | LEAAS | YFSND | SVMNTST |
| Case 6 | 3981 | 2114 | 11,790 | 202 | 40.3 | 38.2 | 3.3 | 120 | 5.9 | Wild | LEEAS | YFSND | SVMNTNT |
| Case 7 | 3591 | 1805 | 44,181 | 728 | 39.8 | 37.9 | – | 102 | 5.7 | Wild | LEEAS | YFSND | SVMNTNT |
| Case 8 | 955 | 548 | 9716 | 455 | 38 | 37.5 | 0.9 | 108 | 5.7 | Wild | LEAAS | YYSND | SVMNTST |
| Case 9 | 4258 | 2104 | 36,847 | 107 | 39.5 | 38 | 2 | 114 | 5.5 | Wild | LEAAS | YFSND | CVIETNT |
PCT represented Parasite clearance time (in h) and parasite clearance half-life was denoted as PC1/2 (in h). We have presented parasite density as PD. Individual ex-vivo ring stage survivability of parasite isolates was represented as RSA(0–3 h). Underline codons were mutant codon. In case 8, RSA(0–3 h) was recorded 0.94% with PC1/2 of 5.7 h while case 7 was failed to culture adaptation. The day-3 parasite load was ranging from 1.8 to 14.2% from that of day-0 parasitaemia.