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. 2021 Apr 28;12:662782. doi: 10.3389/fimmu.2021.662782

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Copyright © 2021 Radke, Li, Hernandez, El Bannoudi, Kosakovsky Pond, Shopsin, Lopez, Fenyö and Silverman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Classical multidimensional scaling on sequence dissimilarity matrix of the VDJ regions from all of the B cell transcripts. Matrix is derived from pairwise longest common substring distance of the all VH sequences from sorted B cells, with dissimilarity between these antibody gene rearrangements depicted in two-dimension. The non-VH3 (circles - VH1, pluses - VH2, diamonds - VH4, ‘X’s - VH5 and sun crosses - VH6), VH3-23 (squares) and VH3-other than from the VH3-23 germline gene (VH3-non23) (triangles) are depicted on the plot. Individual genes are marked with unique colors.