Figure 5.

Alignment of heavy chain variable region sequences of mAbs. The deduced amino acid sequences of recombinant monoclonal IgG antibodies are compared to the VH3-23 germline gene sequence using IMGT-number convention. SpA contact residues with the VH region of the antibodies are highlighted with red boxes with the original numbering used in defining the VH3 Fab-SpA binding interaction below each residue. The natural variation in the mAb SA103, T57K is permissive of the binding interaction (34).