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. 2021 Apr 28;15:643650. doi: 10.3389/fncel.2021.643650

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Copyright © 2021 Hosseini, Michaelsen-Preusse, Schughart and Korte.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H3N2 IAV infection in APPswe/PSEN1dE9 mouse model. (A) 2 months old wild-type (WT) and APP/PS1 mice were infected intranasally with 10 FFU non-neurotropic H3N2 IAV subtype. (B) A representative experiment of body weight loss depicted as a percentage of the starting weight of mice during the acute phase of IAV infection is shown (N = 15 in each group); The body weight loss curve as well as (C) the heat map of body weight loss during 14 days in each group clearly indicated that APP/PS1 mice lost more weight and recover slower compared to WT infected mice. (D) The survival rate of control and infected mice is presented. 100% of control (non-infected WT and APP/PS1 mice) survived while only 88% of WT mice and 76% of APP/PS1 survived from H3N2 IAV infection (N = 25 in each group).