FIGURE 6.

Six months old non-infected and H3N2 IAV infected APP/PS1 mice exhibit reversal learning deficits. (A) During 3 days of reversal learning, non-infected and H3N2 IAV infected APP/PS1 mice showed significantly higher escape latency in comparison with WT. (B) In the probe trial, only non-infected and infected WT mice spent significantly more time in the new target quadrant (T) compared to the average time spent in non-target quadrants (NT). Both non-infected and infected APP/PS1 mice did not show any significant preference for the new target quadrant as it was shown in the occupancy plots as well (N = 7–8 in each group). Data are presented as mean ± SEM, **p < 0.01 and ***p < 0.001 (orange asterisks compared to WT-H3N2, gray asterisks compared to WT-PBS).