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. 2021 Apr 28;15:643287. doi: 10.3389/fnana.2021.643287

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Copyright © 2021 Riquelme, Cerda and Leiva-Salcedo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPM4 inhibition hyperpolarizes CA1 pyramidal neurons during postnatal development. (A) Representative perforated-patch voltage trace recorded in pyramidal neurons showing the effect of 10 μM 9-Ph at P0, P7, P14, and P35. (B) Summary plots showing resting membrane potential and the effect of 10 μM 9-Ph at P0 (n = 6), P7 (n = 6), P14 (n = 6), and P35 (n = 6). (C) Summary plots showing the effect of 9-Ph on the input resistance at P0 (n = 6), P7 (n = 6), P14 (n = 6), and P35 (n = 6; statistical difference were determined using a one-way ANOVA, p-values are show above each group). On the right side of each plot the paired mean difference between the conditions is shown; the mean difference is depicted as a dot; the 95% confidence interval is indicated by the end of the vertical error bar. Statistical differences were evaluated using paired t-test and p-values are shown above. Each point corresponds to an individual mouse (1 slice per mouse).