Table 3.

Computational studies for ligand prediction of olfactory receptors in recent years.

Olfactory receptors	Representative known ligands	Molecule/dataset for computational studies	Research categories and methodologies	Year
OR51E1	Eugenyl acetate; 2,4-dinitrotoluene; methyl furfuryl disulfide	Library of 128 compounds from literature	LBDD. SVM-based virtual screening; QSAR; homology modeling	2018
OR1A1	Ethyl phenylacetate; trans-anethole	Library of 315 compounds from literature	LBDD. SVM-based virtual screening; QSAR; homology modeling	2018
OR2W1	Octanal; benzophenone; eugenyl acetate	Library of 274 compounds from literature	LBDD. SVM-based virtual screening; QSAR; homology modeling	2018
MOR256-3	Benzaldehyde; 2,3-butanediol; coumarin	Library of 73 compounds from literature	LBDD. SVM-based virtual screening; QSAR; homology modeling	2018
OR1G1	Nonanal; 9-decen-1-ol; camphor	Library of 173 compounds from literature	LBDD. SVM; RF; naı ¨ve Bayes; neural network	2018
Olfr73	Isoeugenol; p-isobutylphenol	ZINC database of 1.58 million molecules	SBDD. MD; molecular docking; PH4 search; interaction fingerprint analysis	2019
MOR42-3	α-hexyl cinnamaldehyde	Library of 574 odorants	SBDD. Homology modeling; molecular docking; free energy calculation	2014