Table 4.

Successful cases for the discovery of biased agonists for GPCRs in recent years.

GPCR	Representative biased agonist	Molecule/dataset for computational studies	Research categories and methodologies	Year
MT1/MT2	4-phenyl-2-propionamidotetralin	Library of 8.4 million fragment-like and lead-like compounds	SBDD. Molecular docking	2020
D2R	UNC0006; aripiprazole	Library of about 13000 compounds	SBDD. Homology modeling; molecular docking	2017/2018
5-HT2AR	2,5-dimethoxy-4- nitrophenethylamine	3-(aminoethyl)1-methylindol-5-ol; 5-methyltryptamine; 5-Nitro-1H-indole-3-ethanamine	SBDD. MD; molecular docking; ligand-residue interaction analysis	2015
β2AR	BI-167107	ZINC library of 3.4 million lead-like and fragment-like molecules	SBDD. Homology modeling; molecular docking	2013