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. 2021 Apr 28;8:655157. doi: 10.3389/fmolb.2021.655157

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Copyright © 2021 Liu, Li, Bai and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XIST attenuates high glucose-induced apoptosis and induces autophagy by miR-30d-5p/SIRT1 axis in the HG-treated Schwann cells. (A–C) The HG-treated RSC96 cells are treated with pcDNA-3.1-XIST overexpression vectors, or co-treated with pcDNA-3.1-XIST overexpression vectors and miR-30d-5p mimic or SIRT1 shRNA. (A,B) The apoptosis is detected by flow cytometry analysis. (C) The expression of LC3I, LC3II, and Beclin-1 is assessed by Western blot analysis. N = 3, mean ± SD, **P < 0.01.