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. 2021 Apr 28;12:656103. doi: 10.3389/fphar.2021.656103

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Copyright © 2021 Li, Cheng, Zhang, Tang, Tan, Chen, Wang, Lai and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The potential pathogenesis of COVID-19 and its pathophysiology. After SARS-CoV-2 infection, rapid innate immune response is activated. Then uncontrolled inflammatory responses cause cytokines storm, leading to acute lung injury such as severe respiratory failure. Other multiple organs, such as heart, liver and kidney, are also injured due to the virus and cytokines storm.