Figure 2.

Neutralizing antibodies against SARS-CoV-2 RBD. (A) A cocrystal structure of the RBD (grey) bound to ACE2 (gold) is shown in six orientations (PDB: 6M0J). ACE2 binding site is highlighted in light green. (B) Structures of 38 nAbs were superimposed onto the RBD. Five groups of nAbs are shown in different color tones (1: red, 2: purple, 3: green, 4: blue and 5: yellow). Three non-neutralizing faces are indicated. (C) Maximum of up to four nAbs could potentially bind the RBD simultaneously. (D) Footprints of individual nAbs are shown. To generate footprints, “Clashes/Contacts” tool in UCSF Chimera was used to identify residues on RBD that contact nAbs. Default contact criteria of VDW overlap ≥ -0.4 Å was used. ACE2 contact residues are shown in dark green. Footprints are colored as for panel (B).