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. 2021 Apr 28;12:609693. doi: 10.3389/fphar.2021.609693

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Copyright © 2021 Zhao, Li, Gao, Xu, Zhu, Zhai, Zhang, Shen, Di, Wang, Chen, Huang, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BBR attenuates neuronal apoptosis by inhibiting CNPY2-ERS in ischemic penumbra. The CNPY2-ERS apoptotic signaling proteins CNPY2 (A,B), GRP78 (B), and p-PERK/PERK (D), from cortical ischemic penumbra were determined by Western blot. The results were normalized to the percentage of Calnexin or GAPDH expression. (C,E), Bar graph showing the statistical comparison of CNPY2, GRP78 and p-PERK/PERK protein levels across groups. n = 6. Data are shown as the mean ± SEM. *p < 0.05 compared with the Sham group or Sham + D group; ^# p < 0.05 compared with the CIRI group or CIRI + D group; ^$ p < 0.05 compared with the CIRI + TG group.