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. 2021 Apr 28;12:609693. doi: 10.3389/fphar.2021.609693

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Copyright © 2021 Zhao, Li, Gao, Xu, Zhu, Zhai, Zhang, Shen, Di, Wang, Chen, Huang, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BBR attenuates neuronal apoptosis via the CNPY2-PERK pathway in cortical ischemic penumbra. The CNPY2-PERK apoptotic signaling proteins CHOP (A) and cleaved Caspase-3 (B) from cortical ischemic penumbra were determined by Western blot. The results were normalized to the percentage of GAPDH expression. (B), Bar graph showing the statistical comparison of CHOP and cleaved Caspase-3 protein levels across groups. n = 6. Data are shown as the mean ± SEM. *p < 0.05 compared with the Sham + D group; ^# p < 0.05 compared with the CIRI group; ^▲ p < 0.05 compared with the CIRI + D + BBR group.