TABLE 7.

List of common genes and patterns of inheritance associated with ACM.

Gene	Protein	Mode of inheritance	Disease association	OMIM#	Locus
ACTC1	Actin, alpha, cardiac muscle	AD	ACM, HCM, DCM, LVNC	102540	5q31.1
ARVD3	Arrhythmogenic right ventricular dysplasia, familial, 3	AD	ACM	602086	12p12.1
ARVD4	Arrhythmogenic right ventricular dysplasia, familial, 4	AD	ACM	602087	15q14
ARVD6	Arrhythmogenic right ventricular dysplasia, familial, 6	AD	ACM	604401	1q42-q43
CTNNA3	Catenin alpha 3	AD	ACM	607667	7q21.2
DES	Desmin	AD, AR	ACM, RCM, DCM	125660	17q21
DSC2	Desmocollin 2	AD, AR	ACM, DCM	600271	Xq22
DSG2	Desmoglein 2	AD	ACM, DCM	125671	15q24.1
DSP	Desmoplakin	AD, AR	ACM, DCM	125485	11p15.5
FLNC	Filamin C	AD	ACM, DMC, RCM, HCM	102565	10q22.2
JUP	Junction plakoglobin	AD, AR	ACM	173325	2p13.1
LDB3	Lim domain-binding 3	AD	ACM, HCM, DCM, LVNC	605906	2p22.1
LMNA	Lamin A/C	AD, AR	ACM, HCM, DCM, LVNC	150330	1q22
PKP2	Plakophilin 2	AD	ACM, DCM	602861	11p15.4
PLN	Phospholamban	AD	ACM, HCM, DCM	172405	4q12
RYR2	Ryanodine receptor 2 (cardiac)	AD	ACM, HCM	180902	12p11
SCN5A	Sodium channel, voltage-gated, type V, alpha subunit	AD	ACM, DCM	600163	20q13.12
TGFB3	Transforming growth factor beta 3	AD	ACM	190230
TMEM43	Transmembrane protein 43	AD	ACM	612048	10q23.3
TTN	Titin	AD, AR	ACM, HCM, DCM	188840	5q33-q34

AD, autosomal dominant; AR autosomal recessive; OMIM, online mendelian inheritance in man.