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. 2021 Apr 28;12:655052. doi: 10.3389/fphar.2021.655052

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Copyright © 2021 das Neves, Delivanoglou and Da Mesquita.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme depicting the structure of meningeal lymphatic vessels, lymphatic drainage of CSF solutes/molecules, mechanisms regulating the trafficking of immune cells through meningeal lymphatics and the unidirectional lymphatic flow into the brain draining CLNs. CCL19/21, C–C motif chemokine ligand 19/21; CCR7, C–C motif chemokine receptor 7; COS, confluence of sinuses; CSF, cerebrospinal fluid; LECs, lymphatic endothelial cells; LYVE-1, lymphatic vessel endothelial hyaluronan receptor-1; MMA, middle meningeal artery; PSS, petrosquamosal sinus; RRV, rostral rhinal vein; S1P, sphingosine-1-phosphate; S1PRs, sphingosine-1-phosphate receptors; SMCs, smooth muscle cells; SS, sigmoid sinus; SSS, superior sagittal sinus; TS, transverse sinus. Created with BioRender.com.